Do you think patients who have lenses made based on PD measurements made independently of the frames they'll be wearing end up with PDs that are significantly off?

More and more people are wearing frames without pads and I've seen those sit quite askew. I saw one person who has one eyebrow covered by the frame and another not because the frame is so askew.

Do you see these kind of wrong PDs possibly doing any serious permanent damage? What do you think the effects can be?